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yan zheng yu zuo zuo
Author(s): 
Pages: 582-586
Year: Issue:  6
Journal: Journal of International Neurology and Neurosurgery

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Abstract: 癫痫是一种以反复发作性大脑神经元异常放电致短暂性大脑功能异常为特征的慢性疾病.由癫痫发作引起的脑组织炎症反应是癫痫发作后脑组织病理改变的主要原因.目前,越来越多证据表明炎症反应和癫痫发作之间存在相互促进作用.本文就近几年来证实的参与癫痫发作的多种炎性因子(如IL-1β、TNF-α、COX-2、TGF-β等)和相关受体(如TLR、IL-1R等)进行概述,并探讨不同炎症因子及受体在癫痫发作中的作用机制,进一步说明炎症反应与癫痫发作的关系.
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