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Value of MRI Lesion Volume and BDNF in the Evaluation of Ischemic Strokes Disease Condition and Prognosis
Author(s): 
Pages: 1800-1803
Year: Issue:  12
Journal: Journal of Clinical Radiology

Keyword:  Ischemic strokeLesion volumeBrain-derived neurotrophic factorDisease conditionPrognosis;
Abstract: 目的 研究MRI梗死体积和脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)在缺血性脑卒中病情及预后评估中的价值.方法 选择缺血性脑卒中为研究对象,分析不同临床因素中病灶体积及BDNF的差异,分析缺血性脑卒中预后的危险因素,比较不同病灶体积及BDNF下生存质量的差异.结果 有高血压病史及NIHSS评分≥20分患者病灶体积显著高于无高血压病史及NIHSS评分<20分患者,而BDNF显著低于无高血压病史及NIHSS评分<20分患者.有严重并发症及死亡患者病灶体积显著高于无严重并发症及存活患者(均P<0.05),而BDNF显著低于无严重并发症及存活患者(均P<0.05),Logistic回归分析表明病灶体积≥8.5 cm3和BDNF< 6.1 ng/ml均为有严重并发症及死亡的独立危险因素(均OR>1).缺血性脑卒中研究对象病灶体积<8.5cm3和BDNF≥6.1 ng/ml患者生理功能、生理职能、躯体疼痛、总体健康、精力、社会功能、情感职能和精神健康评分均显著高于病灶体积≥8.5 cm3和BDNF<6.1 ng/ml患者(均P<0.05).结论 MRI病灶体积和BDNF均可用于缺血性脑卒中病情及预后评估,病灶体积≥8.5 cm3和BDNF< 6.1 ng/ml均为预后不良的危险因素.
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