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Correlation on MRI Non-Morphological Features and Her-2 Expression of Colorectal Cancer
Author(s): 
Pages: 1843-1847
Year: Issue:  12
Journal: Journal of Clinical Radiology

Keyword:  Rectal cancerMagnetic resonance imaging;
Abstract: 目的 分析直肠癌MRI非形态学表征(血流动力学、功能学)与Her-2表达水平的相关性.方法 回顾性分析56例经手术病理证实的直肠癌患者,术前行盆腔常规MRI、直肠DWI及增强扫描,分别记录病灶时间-信号强度曲线、早期强化率,测量ADC值,应用t检验、x2检验及非参数Spearman秩相关与Her-2表达水平进行相关分析.结果 直肠癌时间-信号强度曲线、早期强化率与Her-2表达无明确相关.ADC值与Her-2表达程度呈负相关(r=-0421,P=0.001 <0.05).非参数多个样本Kruaskal-Wallis检验法分析显示:Her-2表达程度不同组间病灶ADC值间差异具有统计学意义(F=6.010,P=0.003 <0.05).应用ROC曲线分析显示,判断Her-2表达的最佳ADC值诊断界值为1.160×10-3mm2/s.结论 直肠癌血流动力学指标尚不足以反映Her-2表达程度,而ADC值与Her-2表达程度呈负相关,ADC值能在一定程度上间接评价肿瘤增殖及预后.
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