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MRI Manifestations and the ADC and rADC Values of Primary Central Nervous System Lymphoma and Correlation with the Expression of Ki-67 and bcl-2
Author(s): 
Pages: 1790-1795
Year: Issue:  12
Journal: Journal of Clinical Radiology

Keyword:  LymphomaPrimaryCentral Nervous SystemMagnetic resonance imagingApparent diffusion coefficient;
Abstract: 目的 探讨原发性中枢神经系统淋巴瘤(PCNSL)3.0 T MRI征象及表观扩散系数(ADC)值、相对表观扩散系数(rADC)值与Ki-67、Bcl-2表达的相关性.方法 分析46例经术后病理证实的PCNSL患者的MRI常规及功能成像特征,并测定其ADC、rADC值.病理采用免疫组织化学染色并检测Ki-67和bcl-2蛋白表达情况,分析肿瘤MRI征象及ADC值、rADC值与Ki-67、bcl-2表达的关系.结果 PCNSL发生的部位、是否靠近中线或脑室等与Ki-67、bcl-2的高表达水平无关(P>0.05),而肿瘤直径≥3 cm,内部囊变、坏死、出血,侵及邻近脑膜及室管膜,明显强化,边界不清晰,中或重度瘤周水肿,DWI呈稍高或高信号与Ki-67、bcl-2的高表达具有显著相关性(P<0.05).Ki-67、bcl-2低表达组的ADC值、rADC值显著高于高表达组(P<0.05),肿瘤Ki-67、bcl-2的表达程度与ADC值、rADC值呈显著负相关.Ki-67与bcl-2表达密切相关,二者呈明显正相关(r=0.772,P=0.000).结论 3.0TMRI征象及ADC值、rADC值能在一定程度上反映PCNSL的生物学特性,可间接评价其相关基因的表达,有利于术前无创性评估肿瘤的恶性程度,为PCNSL的预后和治疗提供新的有价值的依据.
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