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Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies
Author(s): 
Pages: 219-237
Year: Issue:  2
Journal: Neuroscience Bulletin

Keyword:  Autism spectrum disorderBiomarkerNeuroimagingStructural MRIDiffusion tensor imagingResting-state functional MRIMagnetic resonance spectroscopyChildrenHuman;
Abstract: Searching for effective biomarkers is one of the most challenging tasks in the research ?eld of Autism Spectrum Disorder(ASD). Magnetic resonance imaging(MRI) provides a non-invasive and powerful tool for investigating changes in the structure, function, maturation,connectivity, and metabolism of the brain of children with ASD. Here, we review the more recent MRI studies in young children with ASD, aiming to provide candidate biomarkers for the diagnosis of childhood ASD. The review covers structural imaging methods, diffusion tensor imaging, resting-state functional MRI, and magnetic resonance spectroscopy. Future advances in neuroimaging techniques, as well as cross-disciplinary studies and largescale collaborations will be needed for an integrated approach linking neuroimaging, genetics, and phenotypic data to allow the discovery of new, effective biomarkers.
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