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Genes Related to Oxytocin and Arginine-Vasopressin Pathways:Associations with Autism Spectrum Disorders
Pages: 238-246
Year: Issue:  2
Journal: Neuroscience Bulletin

Keyword:  OxytocinArginine-vasopressinSinglenucleotide polymorphismsAutism spectrum disorder;
Abstract: Autism spectrum disorder(ASD) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions, communication de?cits, and repetitive behavior. Although the mechanisms underlying its etiology and manifestations are poorly understood,several lines of evidence from rodent and human studies suggest involvement of the evolutionarily highly-conserved oxytocin(OXT) and arginine-vasopressin(AVP), as these neuropeptides modulate various aspects of mammalian social behavior. As far as we know, there is no comprehensive review of the roles of the OXT and AVP systems in the development of ASD from the genetic aspect. In this review, we summarize the current knowledge regarding associations between ASD and single-nucleotide variants of the human OXT-AVP pathway genes OXT, AVP, AVP receptor 1a(AVPR1a), OXT receptor(OXTR), theoxytocinase/vasopressinase(LNPEP), and ADP-ribosyl cyclase(CD38).
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