The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Engineering of the thiostrepton biosynthetic pathway based on mutation and modification of the active structural moieties
Pages: 189-197
Year: Issue:  3
Journal: Chinese Journal of Antibiotics

Keyword:  ThiopeptideThiostreptonAction mechanismBiosynthesisStructural modification;
Abstract: Thiopeptide antibiotics are a class of sulfur-rich and highly modified polypeptide compounds,exhibiting potent activities against bacterial pathogens.As an archetypal bi-cyclic thiopeptide,thiostrepton has received great attention from researchers at home and abroad.This review introduces the biological activities,the action mechanisms and the biosynthetic studies of thiostrepton.A biosynthetic pathway engineering concept based on mutation and modification of the active structural moieties of thiostrepton is proposed,which could generate more thiostrepton analogues with better activities.According to the characteristics of thiostrepton biosynthesis,three main engineering strategies are classified and the corresponding examples are discussed.This review will provide a new perspective to the studies on the biosynthetic mechanisms and structural engineering of the thiostrepton-related natural products.
Related Articles
No related articles found