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Study on mutant selection window of Cefotaxime combination with Enrofloxacin against Escherichia coli isolated from cattle with F17 virulence genes
Pages: 34-37
Year: Issue:  1
Journal: Chinese Journal of Preventive Veterinary Medicine

Keyword:  Escherichia coli from cattleF17 virulence geneMSWMPCdrug combination;
Abstract: To study the effect of antibiotics combination on the mutant selection window (MSW) of Escherichia from cattle with F17 virulence gene, the minimum inhibitory concentration (MIC) of Cefotaxime and Enrofloxacin and the mutant prevention concentration (MPC) both sole and combined were determined by the method of agar plate dilution method, and the value of selection index (SI) of MPC/MIC was acquired. The results showed that the MPC90 of Cefotaxime dropped to 256 mg/L, the value of SI decreased by 4 fold and the MPC90 to MIC90 ratio was 1, which indicated that the MSW was closed after Cefotaxime combined with Enrofloxacin. Whilst the MPC90 of Enrofloxacin was reduced to 256 mg/L, the value of SI decreased by 2 fold and the MPC90 to MIC90 ratio was 2, which demonstrated that the MSW was narrowed. The study showed that Cefotaxime combined Enrofloxacin can contract even close the mutant selection window and prevent the formation of drug resistance.
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