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Study on the Influence of Bifidobacterium Quadruplex Combined with Oryzanol on Serum Levels of TNF-α、IL-6 in Female Patients with Irritable Bowel Syndrome
Author(s): 
Pages: 2136-2139
Year: Issue:  11
Journal: Journal of Clinical Research

Keyword:  Irritable Bowel SyndromeProbiotics/TUCoumaric Acids/TUPhytosterols/TUTabletsTumor Necrosis Factor-alphaInterleukin-6;
Abstract: [目的]探讨双歧杆菌四联活菌联合谷维素治疗女性肠易激综合征的疗效及其对患者血清TNF-α、IL-6的影响.[方法]肠易激综合征患者86例,随机分为两组,每组43例.对照组:给予常规支持治疗.观察组:在对照组常规治疗的基础上加用谷维素及双歧杆菌四联活菌治疗.比较两组临床疗效,精神状态及炎性因子水平.[结果]观察组总有效率为95.35%高于对照组总有效率72.09%,差异具有统计学意义(P<0.01).治疗后,观察组患者症状严重程度、症状频率评分均低于对照组,差异均有统计学意义(P<0.01).治疗后,观察组汉密尔顿抑郁量表(H AMD)评分(10.41±2.50)分和和汉密尔顿焦虑量表(HAMA)评分(10.24±2.68)分低于对照组HAMD评分(12.92±3.16)分和HAMA评分(12.63±3.35)分,差异具有统计学意义(P<0.01).治疗后,观察组血清TNF-α水平(29.72±11.75) pg/mL、IL-6(11.23±3.15)ng/L均低于对照组血清TNF-α水平(43.56±12.47) pg/mL、IL-6(17.91±4.17)ng/L,差异均有统计学意义(P<0.01).[结论]双歧杆菌四联活菌联合谷维素用于治疗肠易激综合征疗效确切,可有效改善胃肠道功能及血清TNF-α、IL-6水平,提高患者生活质量.
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