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man xing jian xie di yang dui zhi fang zu zhi il-6 tnf- ji yin biao da de ying xiang
Author(s): 
Pages: 17-17,18
Year: Issue:  12
Journal: China Prescription Drug

Keyword:  慢性间歇低氧脂肪组织IL-6TNF-α;
Abstract: 目的:探讨慢性间歇低氧(CIH)对内脏脂肪组织IL-6、TNF-α基因表达的影响。方法选用12周龄C57BL/6雄性小鼠16只,随机平均分为正常组(CON组,n=8)、慢性间歇低氧组(CIH组,n=8)。CON组在正常环境下饲养,CIH组低氧暴露时间为每日8:00~16:00,每周6天,共5周。于5周末取血,用ELISA法测量血清IL-6和TNF-α;取肾周脂肪组织观察形态学改变,并采用Real time-qPCR检测IL-6和TNF-α肾周脂肪组织mRNA表达情况。结果与CON组相比,CIH组小鼠肾周脂肪细胞直径明显下降(P<0.05);而血清IL-6和TNF-α水平均明显升高;脂肪组织IL-6和TNF-αmRNA表达升高。结论CIH能促进脂肪组织IL-6、TNF-αmRAN的表达。
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