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Observation on Efficacy of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Sodium Hyaluronate Eye Drops in Treatment of Xerophthalmia
Author(s): KUANG Huimin, ZHANG Hanbin, Dept.of Ophthalmology, Hubei Hanchuan People’s Hospital
Pages: 1626-
1628
Year: 2016
Issue:
12
Journal: Evaluation and Analysis of Drug-Use in Hospital of China
Keyword: Recombinant bovine basic fibroblast growth factor eye drops; Xerophthalmia; Clinical efficacy;
Abstract: OBJECTIVE: To probe into the clinical efficacy of recombinant bovine basic fibroblast growth factor combined with sodium hyaluronate eye drops in treatment of xerophthalmia. METHODS: 90 patients xerophthalmia admitted into Hanchuan Prople’s Hospital from Feb. 2014 to Nov. 2015 were selected to be divided into observation group and control group via the number grouping method,with 45 cases in each. The control group were treated with sodium hyaluronate eye drops,while the observation group additionally received recombinant bovine basic fibroblast growth factor eye drops based on the control group. RESULTS: The total effective rate of observation group was 95. 56%( 43 /45),significantly higher than that of control group 82. 22%( 37 /45),with statistically significant difference( P < 0. 05). After treatment,the tear breakup time of observation group was significantly higher than that of control group,yet SAI and SRI indicators were significantly lower than those of control group,with statistically significant difference( P < 0. 05). CONCLUSIONS: The efficacy of recombinant bovine basic fibroblast growth factor combined with sodium hyaluronate eye drops in treatment of xerophthalmia is remarkable with few adverse drug reactions and high safety.
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