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Bifurcation Analysis of p53 Dynamics Mediated by PDCD5
Author(s): 
Pages: 561-567
Year: Issue:  6
Journal: Acta Scientiarum Naturalium Universitatis Neimongol

Keyword:  PDCD5dosage of ETSdegradation rate of active ATMbifurcation analysis;
Abstract: Tumor suppressor protein p53 plays a key role in the DNA damage response.The modules with DNA damage induced by ETS and the activation of ATM are added to p53-Mdm2 oscillator model mediated by PDCD5.Through bifurcation analysis,p53 dynamics mediated by PDCD5 and the dosage of ETS is firstly explored.The dynamics of system changes from a single steady state to oscillation due to the supercritical Hopf bifurcation with the increasing of PDCD5 level at any ETS dosage.Secondly,the effects of PDCD5 and the active ATM degradation rate on p53 dynamics are discussed.With the change of these two parameters,p53 exhibits rich dynamics,including a single steady state,two steady states,oscillation and the bistability with a single steady state and oscillation.These results show that the effect of these parameters on p53 dynamics is helpful for understanding the regulation of p53 signaling pathway after DNA damage.
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