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Effect and Mechanism of Qingxuan Jiangya Decoction on Hypertension Patients with Liver Yang Hyperactivity
Author(s): 
Pages: 151-153
Year: Issue:  7
Journal: Journal of Liaoning College of Traditional Chinese Medicine

Keyword:  Qingxuan Jiangya Decoctionhyperactivity of liver Yanghypertension;
Abstract: Objective:To figure out the efficacy of Qingxuan Jiangya Decoction on hypertensive patients with medium or low risk and I or Ⅱ grade and the type of hyperactivity of liver Yang,furthermore,discussing its antihypertensive mechanism by detecting the RAAS related hormones including serum ACE,Renin,ANG-2 and ALD. Methods:This study is open prospective randomized controlled trial divided 172 hypertensive patients with medium or low risk and I or II grade and the type of hyperactivity of liver Yang into 2 groups randomly,with each group of 86 patients. The control group only given fosinopril and the treatment group was given Qingxuan Jiangya Decoction and fosinopril combined treatment,respectively comparing blood pressure,trough/peak ratio,RAAS related hormone levels,efficacy,TCM syndrome score,side effects after 1 and 2 weeks. Results:Treatment of 1 week,the treatment group of 24 hours average blood pressure,ANG-2 and ALD levels were significantly decreased compared with those before treatment(P<0.05),there is a decreasing trend of ACE and Renin values,but no significant difference(P>0.05);two groups of RAAS related hormone including ACE,Renin,ANG-2,ALD and trough/peak ratio,the total efficiency,TCM syndrome score have no statistical difference(P>0.05). Treatment of 2 weeks,the treatment group of 24 hours average blood pressure,ANG-2 and ALD levels further reduced then that treated of 1 week(P<0.05),but the change of ACE and Renin had no statistical difference(P>0.05);24-hour mean blood pressure,daytime accept systolic blood pressure,ANG-2 and ALD levels of treatment group decreased significantly compared with the control group(P<0.05);trough/peak ratio,the total efficiency rate,TCM syndrome integral in the treatment group were obviously better than that of the control group. Conclusion:Antihypertensive effect of Qingxuan Jiangya Decoction combined with ACE inhibitor is better than western medicine alone to hypertensive patients with medium or low risk and I or II grade and the type of hyperactivity of liver Yang. It may be achieved by lowering the level of angiotensin II and aldosterone to achieve the desired goal of reducing blood pressure.
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