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Influence of Ginsenoside Rb1 on Expression of Phosphorylated MAP-2 in Hippocampus and Amygdala of CUMS Rat
Pages: 47-49
Year: Issue:  7
Journal: Journal of Liaoning College of Traditional Chinese Medicine

Keyword:  ginsenoside Rb1stresshippocampusamygdalamicrotubule-associated protein;
Abstract: Objective:To observe the effcet of ginsenoside Rb1 on phosphorylation of microtubuleassociated protein 2(p MAP-2)in hippocampus and amygdala of depressive rats. Methods:Thirty male Wistar rats were randomly divided into control group,stress group and treatment group. The stress group rats were gave the chronic unpredicted mild stress and the treatment grous rats were gave ginsenoside Rb1. The behavior changes were examined using sucrose preference test and open-field test. The expression of p MAP-2 protein and m RNA were detected by Western blot and real-time PCR respectively. Results:(1)Compared to control rats,preferce of sucrose and score of open-field test of stress group rats were significantly lower,while the escape latency were higher(P<0.05). These index were reversed in treatment group.(2)The expression of p MAP-2 protein and m RNA of stess group were lower than that of control group,while the index was higher after treatment with ginsenoside Rb1(P<0.05). Conclusion:Effect of ginsenoside Rb1 antidepressant may induced by affect the phosphorylation of MAP-2 in hippocampus and amygdala.
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