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Effect and Mechanism of Schisandra on Treating Vitamin A-deficient Dry Eye Syndrome
Pages: 33-35
Year: Issue:  7
Journal: Journal of Liaoning College of Traditional Chinese Medicine

Keyword:  dry eye syndromevitamin A deficiencySchisandraIL-6TNF-α;
Abstract: Objective:Investigate the efficacy of Chinese medicine Schisandra to vitamin A-deficient dry eye syndrome and corneal tissue IL-6,TNF-α expression changes,compare the number of apoptotic cells in the lacrimal gland. Methods:180 white leghorn chicken,randomization,and start feeding. All animals were divided into normal control group,model group(vitamin A deficient)and Schisandra group. The Schirmer I test(SIT)and tear film breakup time(BUT)were tested before treatment,after treatment two weeks and four weeks after treatment for each group Leghorn chickens. Fluorescein staining of the cornea and by immunohistochemistry IL-6 and TNF-α,lacrimal gland of each group number of apoptotic cells. Results:Medication two weeks,four weeks later,compared with the model group,Schirmer test paper changed significantly longer wet,tear breakup time gradually increased,increased corneal surface moisture,a small amount of fluorescein dye coloring. Immunohistochemistry detected IL-6 and TNF-α were significantly lower in the group of Leghorn corneal epithelial cells,apoptosis were relieved lacrimal gland. Conclusion:Schisandra can increase the secretion of tear,maintain the stability of tear film,its mechanism may be the inhibition of lacrimal gland cell apoptosis,inhibition of IL-6 and TNF-αexpression,inflammatory reaction.
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