Study on the Synthesis of 2,4-dichlorobutyrophenone
Author(s): Wu Xiang, Ma Yong, Yang zhenyu, Tian Xiuzhi, Jiangsu Yangnong Chemical Group Co., Ltd.
Pages: 71-72
Year: 2016 Issue: 22
Journal: Guangdong Chemical Industry
Keyword: m-dichlorobenzene; butyryl chloride; Friedel-Grafts acylation; 2; 4-Dichlorobutyrophenone;
Abstract: 2,4-Dichlorobutyrophenone was synthesized via Friedel-Grafts acylation using m-dichlorobenzene and butyryl chloride as the material. The effects of the ratio of reagents, adding temperature and reaction temperature to the yield of 2,4-Dichlorobutyrophenone.The results showed that the optimal condition molar ratio of m-dichlorobenzene aluminium chloride and butyryl chloride were 1.5∶1.5∶1, adding temperature was heated at 40 ℃ for 0.5 h and then at reaction temperature with 110 ℃ for 2 h, the yield of 2,4-Dichlorobutyrophenone was about 94.4 %.
Pages: 71-72
Year: 2016 Issue: 22
Journal: Guangdong Chemical Industry
Keyword: m-dichlorobenzene; butyryl chloride; Friedel-Grafts acylation; 2; 4-Dichlorobutyrophenone;
Abstract: 2,4-Dichlorobutyrophenone was synthesized via Friedel-Grafts acylation using m-dichlorobenzene and butyryl chloride as the material. The effects of the ratio of reagents, adding temperature and reaction temperature to the yield of 2,4-Dichlorobutyrophenone.The results showed that the optimal condition molar ratio of m-dichlorobenzene aluminium chloride and butyryl chloride were 1.5∶1.5∶1, adding temperature was heated at 40 ℃ for 0.5 h and then at reaction temperature with 110 ℃ for 2 h, the yield of 2,4-Dichlorobutyrophenone was about 94.4 %.
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