Influences of Salvia on Lipid Metabolism and Adipocytokines in Rats with Non-alcoholic Steato-hepatitis
Author(s): TAN Zhaohui, ZOU Lihua, LIU Ronghuo, XIE Lihua, HU Hongsong, Longgang Disetrict People’s Hospital
Pages: 40-42
Year: 2016 Issue: 9
Journal: Journal of Liaoning College of Traditional Chinese Medicine
Keyword: salvia injection; non-alcoholic steato-hepatitis; adiponectin; tumor necrosis factor alpha(TNF-α);
Abstract: Objective:To study the effect of salvia injection on lipid metabolism,hepatic tissue pathological change,and adipocytokines in rats with non-alcoholic steato-hepatitis(NASH),and to discuss the mechanism. Methods:Non-alcoholic steato-hepatitis SD rats model were established by administering a high-fat diet for 16 weeks and were treated with salvia injection at dosages of 5 m L/ kg body weight/d. Pathological changes of liver tissues were observed with HE. Liver index and rats’ wet liver weight were measured. The serum levels of total cholesterol(TC),triglycerides(TG),adiponectin(APN),tumor necrosis factor alpha(TNF-α)were measured,and the liver homogenate levels of TC,TG were measured. Results:At the end of 16 th week,liver index and rats’ wet liver weight,the serum levels of TC,TG,TNF-α,as well as the liver homogenate levels of TC,TG increased(P<0.01),and the level of Adiponectin decreased significantly in model group compared with those in normal group(P<0.01).Liver index and rats’ wet liver weight,the serum levels of TC,TG,TNF-α,as well as the liver homogenate levels of TC,TG were significantly lower(P<0.01)in salvia injection group compared with model group. While the level of APN increased significantly in salvia injection group compared with model group. There were severe steatosis inflammatory cell infiltration and necrotic foci in model group rats. While the degree of fatty degeneration and inflammation were relieved dramatically in salvia injection group. Conclusions:Salvia injection has the effects of regulating the levels of adipocytokines,and relieving steatosis of hepatocytes,so as to be used in treatment on NASH.
Pages: 40-42
Year: 2016 Issue: 9
Journal: Journal of Liaoning College of Traditional Chinese Medicine
Keyword: salvia injection; non-alcoholic steato-hepatitis; adiponectin; tumor necrosis factor alpha(TNF-α);
Abstract: Objective:To study the effect of salvia injection on lipid metabolism,hepatic tissue pathological change,and adipocytokines in rats with non-alcoholic steato-hepatitis(NASH),and to discuss the mechanism. Methods:Non-alcoholic steato-hepatitis SD rats model were established by administering a high-fat diet for 16 weeks and were treated with salvia injection at dosages of 5 m L/ kg body weight/d. Pathological changes of liver tissues were observed with HE. Liver index and rats’ wet liver weight were measured. The serum levels of total cholesterol(TC),triglycerides(TG),adiponectin(APN),tumor necrosis factor alpha(TNF-α)were measured,and the liver homogenate levels of TC,TG were measured. Results:At the end of 16 th week,liver index and rats’ wet liver weight,the serum levels of TC,TG,TNF-α,as well as the liver homogenate levels of TC,TG increased(P<0.01),and the level of Adiponectin decreased significantly in model group compared with those in normal group(P<0.01).Liver index and rats’ wet liver weight,the serum levels of TC,TG,TNF-α,as well as the liver homogenate levels of TC,TG were significantly lower(P<0.01)in salvia injection group compared with model group. While the level of APN increased significantly in salvia injection group compared with model group. There were severe steatosis inflammatory cell infiltration and necrotic foci in model group rats. While the degree of fatty degeneration and inflammation were relieved dramatically in salvia injection group. Conclusions:Salvia injection has the effects of regulating the levels of adipocytokines,and relieving steatosis of hepatocytes,so as to be used in treatment on NASH.
Related Articles