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Extracellular vesicles in promoting the invasion and metastasis of pancreatic cancer
Pages: 947-949
Year: Issue:  12
Journal: Journal of International Oncology

Keyword:  Pancreatic neoplasmsNeoplasm invasivenessNeoplasm metastasisExtracellular vesi-cles;
Abstract: The secretion of extracellular vesicles (EVs)is a well-conserved evolutionary process that occurs from prokaryotic cells to eukaryotes.EVs have been identified in body fluids such as plasma,urine,as-cites,and bile as well as tumor microenvironment.EVs play an important role in cell growth,movement,signal transduction,invasion and metastasis of tumor cells.With a high invasive ability,pancreatic cancer has a high degree of malignancy.Evs can enhance the invasion and metastasis of pancreatic cancer by increasing cell pro-liferation,inhibiting immune responses,promoting angiogenesis and extracellular matrix remodeling.
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