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ABCA1:a new therapeutic target of tumor
Pages: 921-923
Year: Issue:  12
Journal: Journal of International Oncology

Keyword:  NeoplasmsCholesterolATP-binding cassette transporter A1;
Abstract: ATP-binding cassette transporter A1 is one of the important members of the ABC transporter protein family,which plays a very crucial role in cholesterol reverse transport,cholesterol metabolism and the regulation of high-density lipoprotein (HDL)metabolism.Mutation of ABCA1 gene could induce Trangier dis-ease and familial deficiency of HDL.Recent studies have pointed out that ABCA1 could have anti-cancer activi-ty through cholesterol efflux,which will become a promising new therapeutic target of tumor.
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