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Effect comparison between ultrasound guided percutaneous laser ablation and radiofrequency ablation for the treatment of small hepatocellular carcinoma
Author(s): 
Pages: 900-903
Year: Issue:  12
Journal: Journal of International Oncology

Keyword:  CarcinomahepatocellularCatheter ablationProgression-free survival;
Abstract: Objective To compare the effects between ultrasound guided percutaneous laser ablation (LA)and radiofrequency ablation (RFA)for small hepatocellular carcinoma (HHC).Methods We retro-spectively reviewed the data of 54 patients with small HHC.According to the different methods of treatment,54 patients were divided into LA group (n =27)and RFA group (n =27).Patients in LA group were treated with ultrasound guided percutaneous LA,and patients in RFA group were treated with RFA.The adverse reaction and short-term curative effect were observed.The local tumor control rate and progression-free survival (PFS) of patients were follow-up visited.Results After treatment,the total response rates of patients in LA group and RFA group were 81 .48% and 77.78% respectively,with no significant difference (χ2 =0.1 1 ,P =0.74).The 1 -year local tumor control rates of patients in LA group and RFA group were 77.78% and 51 .85%respectively,with a significant difference (χ2 =1 4.74,P =0.00).The median PFS of patients in LA group and RFA group were (1 2.52 ±6.57)months and (8.67 ±5.1 3)months,with a significant difference (χ2 =4.70,P =0.03).The adverse reactions of patients in LA group and RFA group after treatment were puncture region pain (40.74% vs.33.33%;χ2 =0.32,P =0.57),retroperitoneal hemorrhage (7.41 % vs.1 1 .1 1 %;P =0.64),hemobilia (0 vs.3.70%;P =0.31 ),bile leakage (7.41 % vs.1 4.81 %;P =0.39),and ab-dominal infection (3.70% vs.1 1 .1 1 %;P =0.30),with no significant differences.Conclusion Compared with RFA,LA may improve the local tumor control rate and prolong the PFS of patients with small HHC,which has a certain clinical practice value and prospect.
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