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Molecular targeted therapy for glioma stem cells
Pages: 930-934
Year: Issue:  12
Journal: Journal of International Oncology

Keyword:  GliomaStem cellsMolecular targeted therapy;
Abstract: Glioma stem cells (GSCs)are considered to be the root of migration,recurrence,and re-sistance to chemo-radiotherapy in malignant glioma.With molecular targeting drugs becoming widespread in treating other cancers,the ones targeting GSCs could also be successful in the future.At present,relevant stu-dies mainly concentrate in the hedgehog and PI3K pathways,and main representative drugs are cyclopamine and its derivatives,rapamycin and its derivatives,and some classical drugs like arsenic trioxide and metformin also performing the outcome of anti-GSCs.
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