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Study of the chemotherapy-induced retrospective and prospective memory impairment of triple-negative breast cancer patients
Author(s): JIA Qian-qian, XUAN Han, CHENG Huai-dong, CHEN Zhen-dong, Department of Oncology, Second Affiliated Hospital of Anhui Medical University
Pages: 648-
651
Year: 2016
Issue:
10
Journal: Chinese Journal of Cancer Prevention and Treatment
Keyword: breast neoplasms; chemotherapy; prospective memory; retrospective memory;
Abstract: OBJECTIVE A large number of studies have found the presence of memory impairment showed heterogeneity after chemotherapy of breast cancer.But whether it is related to molecular typing is unclear.The objective of this study were to investigate the differences of memory impairment after chemotherapy between triple-negative breast cancer(TNBC)and non-triple-negative breast cancer(NTNBC),and to understand the characteristics of chemotherapy-induced retrospective(RM)and prospective memory(PM)impairment of TNBC.METHODS Sixty breast cancer patients from the Oncology Department of Second Affiliated Hospital of Anhui Medical University from the March 1,2014 to June 30,2015 were taken as the observation group,who had received adjuvant chemotherapy after operation,including 30 cases of TNBC and 30 cases of NTNBC.In addition,60 cases of healthy women volunteers with matched age and education level were selected as the control group.All participants were administered with mini mental state examination(MMSE),retrospective memory(RM)and prospective memory(PM)questionnaires.RESULTS Compared with the healthy control group,the MMSE,RM and PM scores of observation group were respectively(27.08±1.37)points,(17.97±4.34)points and(18.78±4.24)points,and the differences of them were statistically significant(t values were 2.880,-6.486and-8.645,all P<0.05).Compared with the NTNBC group,the MMSE,RM and PM scores of TNBC group were respectively(26.50 ± 1.67)points,(19.30 ± 2.60)points and(20.33 ± 3.50)points,and the differences of them were statistically significant(t values were 3.624,-2.483and-3.018,all P<0.05).CONCLUSION Patients with breast cancer exist different extents of RM impairment and PM impairment after chemotherapy,and the retrospective and prospective memory damages of patients with TNBC are obviously higher than that in patients with NTNBC,which implies that different expressions of hormone receptor may be associated with the occurrence of memory impairment after chemotherapy of breast cancer patients.
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