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Tongxinluo Capsule in the Treatment of Heart Failure:a Meta-analysis
Pages: 2472-2475
Year: Issue:  21
Journal: Research of Traditional Chinese Medicine

Keyword:  heart failureTonqxinluo capsulerandomized controlled trialmeta-analysis;
Abstract: Objective To systematically evaluate the efficacy of Tongxinluo capsule in the treatment of heart failure(HF)patients.Methods We retrieved CNKI,WanFang,PubMed,the Cochrane Library of clinical control trial databases by computer.According to the integration and elimination standard of the literature,we close the randomized controlled trials(RCTs) of Tongxinluo capsule on HF.Two reviewers finished the quality assessment independently,extracted the data and cross checkded.Finally,we used the RevMan 5.3software for the Meta-analysis.Results A total of 27 studies included 2 222 cases of patients,and all of them were ca RRied in China.Jadad score of 27 studies were 1.The meta-analysis results showed that the Tongxinluo capsule group had a significantly higher of efficacy than the control group in terms of the clinical efficacy[OR=3.44,95%CI(2.55,4.64),P<0.000 01],reduced LVESD WMD=-2.66,95%CI(-3.16,-2.16),P<0.00001],increasedleftventricularejectionfraction[WMD = 5.99,95%C/(5.91,6.08),P<0.000 01],reduced LVEDD[WMD=-3.00,95%CI(-3.74,-2.27),P<0.000 01],increased CO[WMD=0.93,95%CI(0.86,1.01),P <0.000 01].Conclusion Tongxinluo capsule can significantly improve the clinical effcacy,which needs to be further confirmed by more large-sample,high-quality RCTs.
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