The Progress of Propofol on Cognitive Dysfunction and Addiction
Author(s): LIANG Xiao-jie, GUAN Rui-li, WANG Tao, LUO Wen-jing, LIU Ming-chao, The Corps of Clinical Medicine, Fourth Military Medical University, Department of Occupational & Environmental Health, Fourth Military Medical University
Pages: 3974-3976+3931
Year: 2016 Issue: 20
Journal: Progress in Modern Biomedicine
Keyword: Propofol; Learning and Memory; Addiction;
Abstract: As a widely used clinical intravenous anesthetic,propofol were mainly used in induction or sustaining of general anesthesia.In recent years,clinical and laboratory studies have found that in addition to anesthesia effect,there are many other non-narcotic effects of propofol Such as lead to cognitive dysfunction during delivery period,and its underlying mechanisms may involves enhancing the activity of inhibitory neurons,inhibiting the activity of excitatory neurons,and inhibiting some neurotran(?)mitter’s generation(such as nitric oxide).Meanwhile,the cases of abuse began to be reported in the medical literature soon after the drug was introduced into clinical practice.And most of the subsequent studies suggest that this addiction and abuse were mainly due to its rewarding effect To further promote the study on the mechanism of its cognitive impairment and addiction,and providing the corresponded treatment and protective measures,this article reviewed the progress of propofol in recentyears on its cognition hazard and potentially addiction.
Pages: 3974-3976+3931
Year: 2016 Issue: 20
Journal: Progress in Modern Biomedicine
Keyword: Propofol; Learning and Memory; Addiction;
Abstract: As a widely used clinical intravenous anesthetic,propofol were mainly used in induction or sustaining of general anesthesia.In recent years,clinical and laboratory studies have found that in addition to anesthesia effect,there are many other non-narcotic effects of propofol Such as lead to cognitive dysfunction during delivery period,and its underlying mechanisms may involves enhancing the activity of inhibitory neurons,inhibiting the activity of excitatory neurons,and inhibiting some neurotran(?)mitter’s generation(such as nitric oxide).Meanwhile,the cases of abuse began to be reported in the medical literature soon after the drug was introduced into clinical practice.And most of the subsequent studies suggest that this addiction and abuse were mainly due to its rewarding effect To further promote the study on the mechanism of its cognitive impairment and addiction,and providing the corresponded treatment and protective measures,this article reviewed the progress of propofol in recentyears on its cognition hazard and potentially addiction.
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