Author(s): XIU Bin-hua, WEI Min, XING Guo-xiang, MA Ying-hui, YAN Zhi-qiang, Department of neurosurgery, Urumqi General Hospital, Lanzhou Command, PLA, Lintong Sanatorium of Lanzhou Military Area Command, Department of neurosurgery, Fourth Military Medical University, Xijing hospital
Pages: 4237-4241
Year: 2016 Issue:  22
Journal: Progress in Modern Biomedicine
Keyword:  Fluid percussion injury; Irbesartan; Apoptosis; AT1 receptor; Neuroprotection;
Abstract: Objective: To investigate the neuroprotective effects of irbesartan on after fluid percussion-induced brain injury in rats.Methods: Traumatic brain injuries(TBI) model was prepared usingfluid percussion injury method and treated with irbesartan. Regional cerebral blood flow(r CBF) and neurological status was evaluated at different time point respectively. Apoptosis was evaluated by Td T-mediated d UTP nick end labeling(TUNEL) staining and active caspase 3 was detected. Results: Compared with sham group rats,the r CBF was decreased to 30% in TBI rats(P<0.05). The neurological score was decreased significantly(P<0.05). TUNEL positive cells and expression of active caspase 3 were increased in the peri-infarct cortex(P<0.05). Blockade of brain(angiotensin Ⅱ type 1)AT1receptors with irbesartan before TBI could increase r CBF and reduce the infarct size on day 7 after TBI and increased neurologicalstatus(P<0.05). TUNEL positive cells and expression of active caspase 3 were decreased in TBI rats after irbesartan treatment(P<0.05).Conclusions: Irbesartan can play neuroprotective effects by inhibiting apoptosis.