Author(s): CUI Yonghui, GAO Jinfang, TAO Yanfei, WANG Yulian, PENG Dapeng, YUAN Zonghui, CHEN Dongmei, National Reference Laboratory of Veterinary Drug Residues, MOA Key Laboratory for the Detection of Veterinary Drug Residues in Food, MOA Laboratory for the Quality and Safety Risk Assessment of Livestock and Poultry Products, College of Veterinary Medicine, Huazhong Agricultural University
Pages: 1994-2007
Year: 2016 Issue:  10
Journal: Environmental Chemistry
Keyword:  perfluoroalkyl and polyfluoroalkyl substances; metabolic pathways; metabolic mechanism; animals;
Abstract: The study reviews the current knowledge regarding the biotransformation of precursors of perfluorinated carboxylic acids and perfluorinated alkanesulfonates in animal models. Most metabolism studies have been performed with rats and mice,relatively few studies have used fish as models. The fluorotelomer acrylates( 8 ∶ 2 FTAc) and polyfluoroalkyl phosphates( PAPs) both can degrade to form fluorotelomer alcohols,then they ultimately degrade to form perfluorinated carboxylic acids. The perfluorinated sulfamides ultimately degrade to form perfluorinated alkanesulfonates.Thus far,biotransformation studies have predominately used the 8 ∶ 2 fluorotelomer alcohol( FTOH)and N-ethyl perfluorooctane sulfonamido ethanol( N-Et FOSE) as the substrate. However,there has been an increasing number of studies investigating 6 ∶ 2 FTOH biotransformation as a result of industry’s transition to shorter-chain fluorotelomer chemistry.