Author(s): LU Zhen, WANG Yu-fen, LI Wen-jun, WANG Jun, Clinical Laboratory Department, People’s Hospital of Honghu Hubei Province, Ultrasound Diagnosis Department, People’s Hospital of Honghu Hubei Province
Pages: 2053-2055+2059
Year: 2016 Issue:  17
Journal: Journal of Hainan Medical College
Keyword:  High-risk stroke population; Carotid plaque; Hyperhomocysteinemia;
Abstract: Objective:To analyze the relationship between hyperhomocysteinemia and carotid plaque features in highrisk stroke population.Methods:A total of 116 cases of high-risk stroke population treated in our hospital were included in study and divided into stable plaque group(n=32cases),unstable plaque group(n=45cases)and mixed plaque group(n=39cases)according to plaque features after carotid artery ultrasonography.Differences in serum levels of homocysteine(Hcy),adhesion molecule,hypersensitive C-reactive protein,lipid,cell fibronectin,and so on were compared among groups,and the correlation between serum Hcy and plaque feature-related indicators was further analyzed.Results:Serum Hcy,sVCAM-1,sICAM-1,hs-CRP,TC,TG,LDL-C and c-Fn values of unstable plaque group were higher than those of stable plaque group and mixed plaque group,and HDL-C value was lower than that of stable plaque group and mixed plaque group(P<0.05);serum Hcy levels in high-risk stroke population were positively correlated with sVCAM-1,sICAM-1,hs-CRP,TC,TG,LDL-C and c-Fn values,and negatively correlated with HDL-C value.Conclusion:Hyperhomocysteinemia can promote the instability of carotid plaque features in high-risk stroke population,and is a high-risk factor of stroke.