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Comparison of allogeneic or autologous hematopoietic stem cell transplant for high-risk peripheral T cell lymphomas
Pages: 952-956
Year: Issue:  11
Journal: Chinese Journal of Hematology

Keyword:  LymphomaT-cellperipheralHematopoietic stem cell transplantationComparative effectiveness research;
Abstract: Objective To evaluate the efficacy of auto-HSCT and allo-HSCT in the treatment of high risk peripheral T cell lymphoma (PTCL).Methods From July 2007 to July 2014,60 cases of high risk PTCL were analyzed retrospectively.Results All 60 patients were at high risk group (carried with IPI≥3),with a median age of 31 (12-58) years old.Of the 60 cases,22 were PTCL-not otherwise specified (PTCL-NOS),22 ALK negative anaplastic large cell lymphoma (ALK-negative ALCL) and 16 angioimmunoblastic T-cell lymphoma (AITL).Twenty-one patients (21/60) received allo-HSCT,and thirty-nine (39/60) auto-HSCT.Before receiving transplantation,40/60 patients were in complete remission (CR),2/60 patients partial remission (PR) and 18/60 patients not remission (NR).In the 40 CR patients before transplant,10 patients received allo-HSCT and 30 patients auto-HSCT,respectively.In the 20 PR/ NR patients before transplant,11 patients received allo-HSCT and 9 patients auto-HSCT,respectively.After a median follow-up of 39 (range 1-96) months,the K-M analysis showed that the 5-year PFS by autoHSCT and allo-HSCT were 61% and 60% (P=0.724),respectively.The 5-year OS by auto-HSCT and alloHSCT were 62% and 61% (P=0.724),respectively.There were no statistically significant differences between auto-HSCT and allo-HSCT.And the cumulative TRM of auto-HSCT and allo-HSCT were 22.7% and 41.8% (P=0.250),respectively within 5-years after transplantation.At the end of the last follow-up,7 and 2 patients relapsed in auto-HSCT and allo-HSCT groups respectively,the 5-year cumulative recurrence rates of auto-HSCT and allo-HSCT transplantation were 37.2% and 10.1% (P=0.298),respectively.Conclusion There was no significant difference in the long-term survival between auto-HSCT and alloHSCT for high risk PTCL patients.Outcome by allo-HSCT may be better for NR patients.
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