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CHEMICAL CONSTITUENTS OF SEPARATION PART OF ETHYLACETATE IN WATER-DECOCTED LIQUID OF JIEDU HUAYU PRSCRIPTION OF TRADITIONAL CHINESE MEDICINE
Author(s): 
Pages: 297-299
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  drugschinese herbaldetoxificating and stasis-removingethylacetatechromatographyhigh pressure liquidmass spectrometryanalytical chemistry;
Abstract: Objective To analyze the chemical constituents of sepeartion part of ethylacetate in water-decocted liquid of JIEDU HUAYU traditional Chinese medicine. Methods Applying HPLC-MS method,taking methanol-water as mobile phase,gradient elution with velocity of flow as 1mL·min-1,mass-spectrometric detection was done using ESI positive ion mode,scanning range of relative molecular mass was 50-1 000m/z.The detected relative molecular mass data were compared with Aglient traditional Chinese medicine composition database.For compounds with their score of similarity of more than 80% were selected for literature retrieval and source of medicinal herbs identification. Results A total of 18compounds-2-O-cinnamoyl-β-glucose,epimedoside C,reidin A,apiole,9-,10-dimethoxypterocarpan-3-O-β-D-glucoside,carvone,2-O-cinnamoyl-β-glucose,chrysophanol,reidin A,and so on-were identified.2-O-cinnamoyl-β-glucose,reidin A and chrysophanol originated from rheum;9-and10-dimethoxypterocarpan-3-O-β-D-glucoside,isomucronulatol,and kumatakenin originated from astragalus membranaceus;apiole,carvone and capillartemisin B from capillary artemisia;Epimedoside C and 1,2-bis(4-hydroxy-3-methoxyphenyl)propan-1,3-diol from epimedium.7,9(11)-dehydropachymic acid,resveratrol,and agrimol C respectively originated from poria cocos,poly-gonum cuspidatum and agrimonia pilosa.Atractylenolide I originated from atractylodes macrocephala koidz;Torachrysone 8-O-β-D-glucopyranoside from rheum officinale and polygonum cuspidatum;quercetin originated from agrimonia pilosa,epimedium and ca-pillary artemisia. Conclusion Employing HPLC-MS technology,the chemical constituents of separation part of ethylacetate in water extract of JIEDU HUAYU traditional Chinese medicine can be identified,which provides theory basis for clinical application of this prescription.
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