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RISK FACTORS FOR SEVERITY OF BRONCHOPULMONARY DYSPLASIA IN VERY PRETERM INFANTS
Author(s): 
Pages: 348-351
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  bronchopulmonary dysplasiainfantprematurerisk factors;
Abstract: Objective To explore the risk factors for severity of bronchopulmonary dysplasia(BPD)in very preterm infants(VPIs). Methods A retrospective analysis was done in 74 cases of VPIs,fetal age ≤29weeks,survived more than 28 days,treated in our department-during the period from January 2012 to August 2015.According to the standard of BPD,they were divided into three groups as:mild group(n=34),moderate group(n=30)and severe group(n=10).Birth condition,maternal condition during pregnancy,and sick infant’s treatment were compared among the three groups.Significant factors noted in the single factor analysis were taken for logistic regression analysis. Results The differences in gestational age,birth weight,maternal perinatal infection,pneumonia,use of the InSure,mechanical ventilation and duration,and positive blood culture among the three groups were statistically significant(F=46.424-86.898,χ2=6.554-12.583,P<0.05).Logistic regression analysis indicated that complicating pneumonia(OR=5.882,P<0.05)and long-time mechanical ventilation(OR=1.468,P<0.05)were independent risk factors for BPD,but applying the InSure technique was a protection factor(OR=0.642,P<0.05). Conclusion Small gestation age,low birth weight,use of mechanical ventilation and pulmonary infection are closely associated with severe bronchopulmonary dysplasia.Strengthening the management of small-gestation-age and low birth-weight premature infants,using NCPAP,reducing mechanical ventilation,shortening mechanical ventilation time,preventing and treating pulmonary infection are important measures for prevention of severe bronchopulmonary dysplasia in very preterm infants.
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