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EFFECT OF MATRINE INJECTION ON MAST CELL DEGRANULATION CAUSED BY SERUM OF PATIENTS WITH CHRONIC AUTOIMMUNE URTICARIA WITH POSITIVE ANTI-FCεRI ANTIBODY
Author(s): 
Pages: 280-282
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  mast cellshistamineautoantibodiesurticaria;
Abstract: Objective To explore the impact of matrine injection on mast cell degranulation caused by serum of patients with chronic autoimmune urticaria(CAU)with positive anti-FcεRI body. Methods Mast cell suspension with a density of 1×105/L-100μL-was added in a 96-hole cell culture plate,of which,50μL of matrine injection(containing matrine 500μg)were added in each hole and incubation for 24h(group A),the other 30 holes added in no-matrine injection(group B),and the other 30 holes were added in 50μL(containing matrine 500μg)served as control group.Serum of the 10 CAU patients was collected and added 50μL in groups A and B,respectively,and serum of 10 healthy subjects was added in the control group.After 20 minutes of incubation,histamine release(HR)and mast cell degranulation rate(MCDR)were observed. Results In group A,MCDR and HR were lower than that in group B,the difference was significant(F=165.081,43 688.714;P<0.05). Conclusion Matrine injection can inhibit the mast cell degranulation,in vitro,caused by serum of chronic autoimmune urticaria patients with positive anti-FcεRI body.
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