The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
THE VALUE OF CYSTATIN C FOR ASSESSING CONDITION OF ACUTE KIDNEY INJURY IN PATIENTS WITH LIVER CIRRHOSIS
Author(s): 
Pages: 325-327+331
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  liver cirrhosisacute kidey injurycystatin Cprognosis;
Abstract: Objective To evaluate the value of cystatin C(CysC)in early diagnosis and prognostic prediction of acute kidney injury(AKI)in patients with liver cirrhosis. Methods Serum levels of CysC and creatinine(SCr)were detected in 825 patients with liver cirrhosis,and the dynamic changes observed.Employing Child-Pugh grading of liver cirrhosis,the incidence of cirrhosis at different levels was analyzed.The relation ship between CysC,SCr and their abnormal rates,association of liver cirrhosis complicated with AKI with its prognosis was analyzed. Results The levels of CysC in the patients gradually elevated and the detection rate of abnormal CysC markedly increased along with heightened of Child-Pugh grading,the indifferences among each grade was significant(F=292.21,q=7.12-19.36,P<0.01;χ~2=24.96,P<0.01).The level of CysC was also elevated along with increased damage of liver function(F=345.56;q=12.48,16.35;P<0.01).The detection rate of abnormal SCr in grade C was higher than that in grades A and B(χ~2=22.89,P<0.01),but the difference in that between grade A and grade B was not significant(P>0.05).In 693 patients with normal SCr,abnormal CysC was noted in 136 patients,accounting for 19.6%.In all the825 patients,159were consistent with AKI diagnostic criteria,the incidence being 19.27%.With the progression of AKI,the levels of CysC in the patients were then elevated(F=62.64,P<0.001),the differences in AKI between the three grades were significant(q=4.77-12.45,P<0.01),the fatality rate and dialysis rate in patients complicating AKI were higher than those without AKI(χ~2=38.01,P<0.01).Dynamic changes of CysC directly influenced the prognosis of the patients,the highest fatality rate and dialysis rate were noted in progressive AKI,followed by stable AKI,all were higher than those with AKI-free(χ~2=82.33,22.37;P<0.01),and the differences in fatality rate and dialysis rate between patients with transient AKI and those without AKI were not significant(P>0.05). Conclusion CysC measurement can early discover renal function injury in patients with liver cirrhosis,its dynamic changes are closely associated with prognosis of patients with cirrhosis.
Related Articles
No related articles found