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SLC1A1 GENE rs3087879 POLYMORPHISM AND ITS ASSOCIATION WITH OBSESSIVE-COMPULSIVE DISORDER
Author(s): 
Pages: 345-347+351
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  compulsive personality disorderglutamate transporterpolymorphismsingle nucleotide;
Abstract: Objective To explore the correlation between glutamate transporter gene solute carrier family 1 member 1(SLC1A1)and obsessive-compulsive disorder(OCD)in Chinese Han population. Methods Employing polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)technique,the SLC1A1 gene of 438 OCD patients and 467 healthy controls was detected.The association of the genotype and allele frequency distribution with OCD was analyzed. Results Three genotypes-C/C,C/G,and G/G-of SLC1A1 gene rs3087879were detected.A comparison between the OCD group and the control group showed the differences were not significant in regard to the frequency distribution of genotype and allele at rs3087879(P>0.05).After stratification by sex and age of onset,no significant differences in distribution of genotype frequency and allele frequency on the site between each group were noted(P>0.05). Conclusion In Chinese Han population,single nucleotide polymorphism rs3087879 in SLC1A1gene may not be associated with the occurrence of obsessive-compulsive disorder.
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