The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
CORRELATION BETWEEN EXPRESSION OF EPSTEIN-BARR VIRUS LATENT MEMBRANE PROTEIN 1 AND TYPE ⅠINTERFERON INDUCED GENES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Author(s): 
Pages: 276-279+282
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  lupus erythematosussystemicherpesvirus 4humanEBV-associate membrane antigenepstein-barr virusinterferon typeⅠ;
Abstract: Objective To investigate the correlation between expression of latent membrane protein 1(LMP-1)and typeⅠinterferon induced genes(ISGs)of Epstein-Barr(EB)virus in patients with systemic lupus erythematosus(SLE). Methods A total of 68 patients with SLE-including 39 with lupus nephritis-and 40 healthy controls were enrolled in this study.Real time reverse transcription polymerase chain reaction(RT-PCR)was used to test the mRNA levels of LMP-1and ISGs,and the correlation between the two expressions was analyzed. Results In SLE group,the level of LMP-1mRNA was higher than that in the control group(U=1 039.0,P<0.05),the expression of LMP-1mRNA in SLE patients was positively correlated with the disease activity score(r=0.22,P<0.05).In SLE group,the expression levels of OASL,ISG15 and LY6Ewere higher than that in the normal control group(U=377.5-725.0,P<0.05),while the difference in MX1 mRNA level between the two groups was not significant(P>0.05).The difference in ISG15 mRNA expression between patients with lupus nephritis and without was significant(U=387.5,P<0.05).The mRNA level of LMP-1was positively correlated with MX1,OASL and ISG15 mRNA level(r=0.003-0.219,P<0.05),but was not significantly correlated with LY6EmRNA(P>0.05). Conclusion EB virus LMP-1is likely by activating the type-1interferon pathway leading to the development and progression of systemic lupus erythematosus.
Related Articles
No related articles found