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ASSOCIATION OF RS2027432 SNP IN NLRP3 WITH PREECLAMPSIA IN CHINESE HAN POPULATION OF SHANDONG PROVINCE
Author(s): 
Pages: 338-340+344
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  genesNLRP3polymorphismsingle nucleotidepre-eclampsiagenetic predisposition to disease;
Abstract: Objective To investigate the association between NLRP3rs2027432 and preeclampsia in Chinese Han population of Shandong province. Methods Applying real-time PCR,polymorphisms distribution of rs2027432 locus in NLRP3 gene were detected in 976 patients with preeclampsia and 1 194 normal pregnant women. Results The differences in genotype and allele distribution of rs2027432 locus in NLRP3 gene between preeclampsia group and normal control group were not significant(P>0.05),but the differences in the three genotypes of NLRP3 between early-onset preeclampsia and normal control group were significant(χ2=6.384,P<0.05). Conclusion There is a correlation between NLRP3rs2027432 and early-onset preeclampsia in Chinese Han population of Shandong province.
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