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DYSOSMIA IN A53T ALPHA-SYNUCLEIN TRANSGENIC SIX-MONTH-OLD MICE
Author(s): 
Pages: 300-302
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  Parkinson diseaseα-synucleinolfactorymovement disorders;
Abstract: Objective To study the changes in olfactory and anxiety-like behavior and its correlation with movement in A53 Ttransgenic Parkinson’s disease model in mice. Methods The 6-month-old experimental mice were generated on a C57BL/6genetic background with wild phenotype,and the wild type mice served as the control group.Using elevated plus-maze test to measure the duration time percentage of open arms and closed arms,travel times and the total distance.Olfactory recognition ability test was used to detect the time that mice smelled the new and old bedding and their total distance.In the fine odor discrimination test,the correct recognition rate of two odors was recorded.The rotarod test was adopted to measure the time that mice staying on the rod. Results Comparing with the control group,the experimental mice spent more time in open arms than close arms in the elevated plus-maze test(t=2.20,P<0.05);in the olfactory discrimination test,the mice spent similar time on the old and the new bedding(P>0.05);in fine odor discrimination test,the mice exhibited no significant differences between two odors which were mixed by different concentration(P>0.05);and in the rotarod test,the time that the experimental mice stayed on the rotarod had no significant changes(P>0.05). Conclusion A53 Ttransgenic mice exhibit olfactory deficits in early phase,being prior to movement disorders.
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