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EFFECT OF HO-1 ON THE EXPRESSIONS OFΑ-SYNUCLEIN AND POLO-LIKE KINASE 2 IN SH-SY5Y CELLS
Author(s): 
Pages: 294-296
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  heme oxygenase-1SH-SY5Ycellsalpha-synucleinpolo-like kinase 2;
Abstract: Objective To investigate the effect of heme oxygenase-1(HO-1)on the expressions ofα-synuclein and Pololike kinase 2(PLK2)in SH-SY5 Ycells. Methods Western blot was used to investigateα-synuclein levels in SH-SY5 Ydopaminergic cells with HO-1transfection for 48 hand PLK2levels in cells treated with HO-1activator cobalt protoporphyrin IX(CoPPIX)for 48 h. Results Overexpression of HO-1induced down-regulation ofα-synuclein in SH-SY5Ycells(t=2.672,P<0.05).PLK2 levels were significantly up-regulated in cells treated with 10 and 25μmol/L CoPPIX(F=30.75;q=7.64,10.78;P <0.01).Conclusion HO-1down-regulates the expression ofα-synuclein,which might be related with the regulation of PLK2 levels.
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