The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
RELATIONSHIP BETWEEN MICROALBUMINURIA AND SERUM INFLAMMATORY CYTOKINES IN PATIENTS WITH HYPERTENSION
Author(s): 
Pages: 341-344
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  hypertensioncoronary diseasealbuminuriainterleukin-6nitric oxide;
Abstract: Objective To investigate the association of microalbuminuria(MAU)with interleukin-6(IL-6),endothelin-1(ET-1),and nitric oxide(NO)in patients with essential hypertension(EH)and explore their changes. Methods This study consisted of 132 EH patients,of whom,47 in MAU-positive group(MAU≥30mg/L),and 85 in MAU-negative group(MAU<30mg/L).Their blood chemistry and serum IL-6,ET-1and NO were detected,and 50 healthy subjects served as normal controls.Results The serum levels of IL-6,ET-1,and systolic pressure of patients in MAU-positive group were obviously higher than that of patients in the MAU-negative group,the difference was statistically significant(F=284-337,P<0.05).The serum NO level in MAU-positive group was lower than that in the MAU-negative group and the control group,the difference being significant(F=239,P<0.05).The difference in MAU,IL-6,ET-1and NO levels among the patients with different blood pressure grading was significant(F=238-325,P<0.05).Multiple regression analysis showed that the IL-6,ET-1,and systolic pressure were positively correlated with MAU(B=0.206-0.594,P<0.05),and NO was negatively correlated with MAU(B=-0.380,P<0.05). Conclusion In vivo inflammatory response is significantly enhanced in hypertensive patients complicated with microalbuminuria and the risk of coronary artery heart attack increases.
Related Articles
No related articles found