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trb3 tgf- mapk xin hao tong lu yu fei xian wei hua
Pages: 373-375
Year: Issue:  3
Journal: Acta Aacademiae Medical Qingdao Universitatis

Keyword:  肺纤维化Tribbles同源蛋白3转化生长因子β丝裂原活化蛋白激酶磷酸酶类综述;
Abstract: Tribbles同源蛋白3(TRB3)可通过介导Smad依赖与非Samd依赖信号通路调控肺纤维化的进程。转化生长因子β(TGF-β)是最强的致纤维化因子,通过与细胞因子及信号通路相互作用,在纤维化过程中发挥重要作用。丝裂素活化蛋白激酶家族(MAPK)信号通路是重要的非Smad依赖途径。本文就TRB3、TGF-β及MAPK信号通路在肺纤维化进程中的作用及相互关系进行综述。
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