Effect of penehyclidine hydrochloride combining a huffing manoeuvre of fentanly on fentanly-induced cough
Author(s): HE Jing, BAO Hongguang, GAO Yufu, SI Yanna, CHEN Lihai
Pages: 1080-1083
Year: 2016 Issue: 11
Journal: The Journal of Clinical Anesthesiology
Keyword: Penehyclidine hydrochloride; Huffing manoeuvre; Fentany-induced cough;
Abstract: Objective To investigate the incidence of pre-induction coughing after intravenous fentanyl,and evaluate the therapeutic efficacy and safety of penehyclidine hydrochloride combining a huffing manoeuvre of fentanly induced cough.Methods Two hundred patients for elective operations were randomly allocated into four groups.Group H:patients were asked to perform huffing manoeu-vre just before the fentanyl injection by the anesthesiologist after demonstrating and guiding patients how to breath.Group P:patients were administered 0.01 mg/kg penehyclidine hydrochloride in 10 min just before the fentanyl injection.Group HP:patients were administered 0.01 mg/kg penehyclid-ine hydrochloride in 10 min and then the patients were asked to perform huffing manoeuvre just before the fentanyl injection by the anesthesiologist after demonstrating and guiding patients,breathing just before the fentanyl injection.group N:patients were given intravenous induction in a certain order. All groups received i.v.fentanyl (4 μg/kg)within 5 s.The incidence of fentany-induced cough (FIC) was recorded for 1 min before the induction of anaesthesia.Results The incidence of FIC was 6 (12%),5 (10%),2 (4%)and 18 (36%)in groups H,P,HP and N,Groups H,P and HP had a significantly lower incidence than that of group N (P < 0.05 ).However,there was no significant difference in the severity among the four groups.There were no significant differences among all the groups.Conclusion Pretreatment with penehyclidine hydrochloride combining a huffing manoeuvre of fentanyl induced cough could significantly reduced the incidence of cough caused by fentanyl injection.
Pages: 1080-1083
Year: 2016 Issue: 11
Journal: The Journal of Clinical Anesthesiology
Keyword: Penehyclidine hydrochloride; Huffing manoeuvre; Fentany-induced cough;
Abstract: Objective To investigate the incidence of pre-induction coughing after intravenous fentanyl,and evaluate the therapeutic efficacy and safety of penehyclidine hydrochloride combining a huffing manoeuvre of fentanly induced cough.Methods Two hundred patients for elective operations were randomly allocated into four groups.Group H:patients were asked to perform huffing manoeu-vre just before the fentanyl injection by the anesthesiologist after demonstrating and guiding patients how to breath.Group P:patients were administered 0.01 mg/kg penehyclidine hydrochloride in 10 min just before the fentanyl injection.Group HP:patients were administered 0.01 mg/kg penehyclid-ine hydrochloride in 10 min and then the patients were asked to perform huffing manoeuvre just before the fentanyl injection by the anesthesiologist after demonstrating and guiding patients,breathing just before the fentanyl injection.group N:patients were given intravenous induction in a certain order. All groups received i.v.fentanyl (4 μg/kg)within 5 s.The incidence of fentany-induced cough (FIC) was recorded for 1 min before the induction of anaesthesia.Results The incidence of FIC was 6 (12%),5 (10%),2 (4%)and 18 (36%)in groups H,P,HP and N,Groups H,P and HP had a significantly lower incidence than that of group N (P < 0.05 ).However,there was no significant difference in the severity among the four groups.There were no significant differences among all the groups.Conclusion Pretreatment with penehyclidine hydrochloride combining a huffing manoeuvre of fentanyl induced cough could significantly reduced the incidence of cough caused by fentanyl injection.
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