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Effect of Yiqihuoxue Decoction on MMP-3 and MMP-7 Protein Expression in Rat Model of Ruptured Lumbar Disc
Author(s): 
Pages: 1-4
Year: Issue:  3
Journal: Journal of Guangxi Traditional Chinese Medical University

Keyword:  益气活血方腰椎间盘破裂TXB2/PGF1αMMP-3MMP-7实验研究;
Abstract: [目的]观察益气活血方对破裂型腰椎间盘突出大鼠组织中MMP-7和MMP-3蛋白表达及血清中TXB2和PGF1α的影响,初步探讨其治疗作用的可能机制.[方法]建立腰椎间盘突出重吸收大鼠模型,随机分为模型组、益气活血方组,每组10只,另设假手术组(n=10),假手术组及模型组灌胃纯净水,益气活血方组灌胃相应的药物,干预3周后处死大鼠,测定血清中TXB2、PGF1α的含量,观察椎间盘组织病理改变及测定MMP-3、MMP-7蛋白表达.[结果]模型大鼠经益气活血方治疗后,其血清TXB2含量和TXBdPGF1α比值均明显下降,PGF1α含量升高,均呈良性变化;益气活血方组与模型组相比较差异有统计学意义(均P<0.05).益气活血方组与模型组比较,MMP-3、MMP-7蛋白表达均增高,差异有统计学意义(P<0.05).[结论]益气活血方治疗腰椎间盘突出症主要作用机制可能与其提高椎间盘组织MMP-3、MMP-7蛋白表达有关.
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