Author(s): YU Zhan, YU Min, JIA Hong-guang, GU Xiang, ZHANG Li-chuan, HUANG Xiao-bing, LIU Ya, SUN Jian-jun, WEI Yong-xiang, Capital Medical University, Affiliated Beijing An Zhen Hospital, Otorhinolaryngology Head and Neck Surgery, Department of Molecular Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Center of Otolaryngology of PLA, Navy General Hospital
Pages: 490-492
Year: 2016 Issue:  5
Journal: Progress of Anatomical Sciences
Keyword:  chitosan; gelatin; micro balloon; CaCO 3;
Abstract: Objective To search for an effective drug carrier to penetrate the round window membrane,the porous gelatin microsphere combined the thermo-sensitive chitosan/ β-GP gelatin was prepared.Methods CaCO₃ template was synthesized chemically,and gelatin CaCO₃ microsphere was prepared by W/0 emulsive solidified method.Then CaCO₃was removed by EDTA,and porous gelatin microsphere was prepared.Scanning electron microscope was utilized for microsphere characterization.Thermo-sensitive drug carrier of chitosan porous gelatin microsphere was obtained by physical mixation of chitosan and β-GP.Results The chitosan/β-GP solution was injectable,the diameters of chitosan/ β-GP gelatin microspheres were about 2 4μm with porous network after freezing and thermo sensitivity.Conclusion Thermo-sensitive drug carrier of chitosan/β-GP gelatin microspheres would be useful for transmembrane drug delivery.