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Effects of Compound Herba Houttuyniae on Myocardial Injury in db/db Mice
Pages: 2362-2366
Year: Issue:  20
Journal: Research of Traditional Chinese Medicine

Keyword:  diabetic cardiomyopathycompound herbahouttuyniatransforming growth factor-beta 1fibronectinglucagon-like peptide-1;
Abstract: Objective To investigate the effects of different extracts from compound Herba Houttuyniae on development of diabetic cardiomyopathy in db / db mice. Methods db / m mice were in the normal group,and db / db mice were divided into six groups according to their treatment ways randomly: model group,metformin hydrochloride group,water extract group,ethanol extract group,volatile oil group,and mixture group( mixture of above three extract) of compound herba houttuyniae(n = 8 for each). The change of body weight and fasting blood glucose( FBG) of mice were detected. Fins,transforming growth factor-beta 1( TGF-β1),fibronectin( FN),glucagon-like peptide-1( GLP-1) were measured by ELISA after treatment with 8 weeks. The structures of myocardial ultrastructure were observed under electron microscope. Results Compared with normal group,the serum level of TGF-β1,FN in ethanol extract group,volatile oil group,and mixture group were decreased(P <0. 05). The level of GLP-1 in treatment groups except metformin hydrochloride group were increased(P <0. 05). And the myocardial ultrastructure were improved especially in mixture group. Conclusion The compound herba houttuynia can lessen the cardiac pathologicalchange,and the mechanism may related to the decrease of the level of TGF-β1,FN and the increase of GLP-1.
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