Positive Qi Deficiency Combined with Blood Stasis is a Significant Pathogenetic Basis of Traditional Chinese Medicine in the Treatment of Liver and Kidney Fibrosis
Author(s): Liu Chenghai, Hao Juan, Tao Yanyan, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, E-Institute of Traditional Chinese Medicine Internal Medicine
Pages: 1471-1476
Year: 2016 Issue: 9
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine
Keyword: Fibrosis of liver and kidney; the same treatment for different diseases; the combination of disease and syndrome;
Abstract: "The same treatment for different diseases" is the embodiment and a reified mode of "the combination of disease and syndrome" in the diagnosis and treatment. It is critical to identify the pathogenesis of syndromes through establishing the treatment options. Chronic liver and kidney diseases feature with the pathgenesis of "positive qi deficiency combined with blood stasis". For its treatment, prescriptions or medications functioning tonifying deficiency and activating blood circulation are adopted. For example, tonifying deficiency and blood-activating therapy involves prescriptions, such as Fuzheng Huayu(FZHY) recipe and Danggui Buxue(DGBX) decoction and angelica mixture of Radix Astragali, presenting favorable efficacy on the protection and treatment of the liver and kidney fibrosis. Experimental studies on the drug compatibility of FZHY recipe found that the main ingredients of the recipe with anti-liver and kidney fibrosis effect were cordyceps(tonifying deficiency) and salvia(activating the blood circulation). Further pharmacological experiments found that FZHY recipe showed anti-liver and kidney fibrosis effects with the common mechanisms, including anti-lipid peroxidation injury, the inhibition of MMP-2/9 activity and the protection of tissue microenvironment, the down-regulation of TGF-β and other pathological signal transduction pathways, the inhibition of myofibroblast activation, and the regulation of fibrotic pathology differential expressions of proteomics involving material metabolism, cytoskeleton, oxidative stress response. These common mechanisms behind drug regulation composed an important biological basis of the pathogenesis, "positive qi deficiency combined blood stasis", of liver and kidney fibrosis.
Pages: 1471-1476
Year: 2016 Issue: 9
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine
Keyword: Fibrosis of liver and kidney; the same treatment for different diseases; the combination of disease and syndrome;
Abstract: "The same treatment for different diseases" is the embodiment and a reified mode of "the combination of disease and syndrome" in the diagnosis and treatment. It is critical to identify the pathogenesis of syndromes through establishing the treatment options. Chronic liver and kidney diseases feature with the pathgenesis of "positive qi deficiency combined with blood stasis". For its treatment, prescriptions or medications functioning tonifying deficiency and activating blood circulation are adopted. For example, tonifying deficiency and blood-activating therapy involves prescriptions, such as Fuzheng Huayu(FZHY) recipe and Danggui Buxue(DGBX) decoction and angelica mixture of Radix Astragali, presenting favorable efficacy on the protection and treatment of the liver and kidney fibrosis. Experimental studies on the drug compatibility of FZHY recipe found that the main ingredients of the recipe with anti-liver and kidney fibrosis effect were cordyceps(tonifying deficiency) and salvia(activating the blood circulation). Further pharmacological experiments found that FZHY recipe showed anti-liver and kidney fibrosis effects with the common mechanisms, including anti-lipid peroxidation injury, the inhibition of MMP-2/9 activity and the protection of tissue microenvironment, the down-regulation of TGF-β and other pathological signal transduction pathways, the inhibition of myofibroblast activation, and the regulation of fibrotic pathology differential expressions of proteomics involving material metabolism, cytoskeleton, oxidative stress response. These common mechanisms behind drug regulation composed an important biological basis of the pathogenesis, "positive qi deficiency combined blood stasis", of liver and kidney fibrosis.
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