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Expression Pattern of BPI/LBP,Nramp and IL-8 Genes in Nothobranchius Guentheriat Different Month Ages and After the Lipopolysaccharide Challenge
Author(s): 
Pages: 327-335
Year: Issue:  4
Journal: Yantai Teachers University Journal, Natural Science Edition

Keyword:  Nothobranchius guentheriagingantibacterial immunity response;
Abstract: Aging degrades the immunity,however,whether this effect is homogeneous or not is obscure. By way of testing the mRNA’s expression level of the related antibacterial genes( BPI / LBP,Nramp,effector molecules and IL- 8,regulatory factors) in the different tissues of the annual Nothobranchius guentheri at the different month ages,the fact is found that these three kinds of genes all show the heterogeneous expression pattern related to the month age and organs. In comparison with the adult fish,the liver tissues of the old fish have more antibacterial genes. After the Lipopolysaccharide Challenge,the old N. guentheri liver’s antibacterial immunity response is weaker. That is,the aging can weaken this response systematically.
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