Clinical study of blood purification combined with ulinastatin on the treatment of acute paraquat poisoning
Author(s): WANG Lei, JIANG Yu-fei, ZHENG Man-lin
Pages: 3143-3145
Year: 2016 Issue: 19
Journal: Hainan Medical Journal
Keyword: Blood perfusion; Hemofiltration; Ulinastatin; Paraquat; Effect;
Abstract: Objective To investigate the clinical curative effect of blood purification combined with ulinastatin on acute paraquat poisoning. Methods A total of 108 cases of patients with acute paraquat poisoning, who admitted to Department of Emergency of Meishan Hospital of Traditional Chinese Medicine from October 2011 to October 2015, were selected and divided into the observation group (n=55) and the control group (n=53) according to the random num-ber method. The control group applied conventional therapy and blood perfusion and filtration treatment, and the observa-tion group was treated with ulinastatin injection 200 000 U, micro pump injection (2 times/d) based on the control group for 5~7 d. The changes of serum TNF-α, IL-6, IL-10, SOD and MDA levels, and complications and efficacy in the two groups were observed. Results After treatment, the serum TNF-α, IL-6, IL-10 and MDA levels of observation group were (24.56±14.78)μg/L, (24.24±10.08)μg/L, (20.54±9.78)μg/L and (2.58±0.99) mmol/L, respectively which were sig-nificantly higher than those of the control group of (29.86 ± 23.10)μg/L, (38.77 ± 15.43)μg/L, (25.40 ± 11.78)μg/L and (3.96 ± 1.35) mmol/L, respectively. SOD level (68.78 ± 29.60) U/L in the observation group was significantly lower than that in the control group of (102.30±29.33) U/L. All the differences were statistically significant (P<0.05). The probabili-ty of pulmonary fibrosis in the observation group was 23.6%(13/55), which was significantly lower than that of the control group of 37.7%(20/53), P<0.05;the improvement rate of the observation group of 36.4%(20/55) was significantly higher than that of the control group of 22.6%(12/53), P<0.05;the mortality rate of the observers group of 40.0%(22/55) was significantly lower than that of the control group of 56.6%(30/53), P<0.05;the survival time of the patients in the ob-servation group was (10.5±5.2) days, which was significantly longer than that of the control group of (8.5±3.7) days, P<0.05. Conclusion Acute paraquat poisoning treated with blood purification combined with ulinastatin can effectively improve multiple organ function of patients, reduce mortality, and prolong the survival time.
Pages: 3143-3145
Year: 2016 Issue: 19
Journal: Hainan Medical Journal
Keyword: Blood perfusion; Hemofiltration; Ulinastatin; Paraquat; Effect;
Abstract: Objective To investigate the clinical curative effect of blood purification combined with ulinastatin on acute paraquat poisoning. Methods A total of 108 cases of patients with acute paraquat poisoning, who admitted to Department of Emergency of Meishan Hospital of Traditional Chinese Medicine from October 2011 to October 2015, were selected and divided into the observation group (n=55) and the control group (n=53) according to the random num-ber method. The control group applied conventional therapy and blood perfusion and filtration treatment, and the observa-tion group was treated with ulinastatin injection 200 000 U, micro pump injection (2 times/d) based on the control group for 5~7 d. The changes of serum TNF-α, IL-6, IL-10, SOD and MDA levels, and complications and efficacy in the two groups were observed. Results After treatment, the serum TNF-α, IL-6, IL-10 and MDA levels of observation group were (24.56±14.78)μg/L, (24.24±10.08)μg/L, (20.54±9.78)μg/L and (2.58±0.99) mmol/L, respectively which were sig-nificantly higher than those of the control group of (29.86 ± 23.10)μg/L, (38.77 ± 15.43)μg/L, (25.40 ± 11.78)μg/L and (3.96 ± 1.35) mmol/L, respectively. SOD level (68.78 ± 29.60) U/L in the observation group was significantly lower than that in the control group of (102.30±29.33) U/L. All the differences were statistically significant (P<0.05). The probabili-ty of pulmonary fibrosis in the observation group was 23.6%(13/55), which was significantly lower than that of the control group of 37.7%(20/53), P<0.05;the improvement rate of the observation group of 36.4%(20/55) was significantly higher than that of the control group of 22.6%(12/53), P<0.05;the mortality rate of the observers group of 40.0%(22/55) was significantly lower than that of the control group of 56.6%(30/53), P<0.05;the survival time of the patients in the ob-servation group was (10.5±5.2) days, which was significantly longer than that of the control group of (8.5±3.7) days, P<0.05. Conclusion Acute paraquat poisoning treated with blood purification combined with ulinastatin can effectively improve multiple organ function of patients, reduce mortality, and prolong the survival time.
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