Clinical study on Sanjie Zhentong Capsules combined with triptorelin in treatment of endometriosis
Author(s): ZUO Xia, ZHANG Kun
Pages: 1616-1620
Year: 2016 Issue: 10
Journal: World Phytomedicines
Keyword: Sanjie Zhentong Capsules; Triptorelin for injection; endometriosis; ALDH; YKL-4; FSH; LH;
Abstract: Objective To investigate the clinical efficacies of Sanjie Zhentong Capsules combined with triptorelin in treatment of endometriosis.Methods Children (90 cases) with endometriosis in Xi’an NO.4 Hospital from May 2012 to May 2015 were divided into control (45 cases) and treatment (45 cases) groups based on different treatment methods. Patients in the control group were im administered with Triptorelin for injection on the second day of the first menstruation after surgery, 3.75 mg/time, once every 4 weeks. Patients in the treatment group werepo administered with Sanjie Zhentong Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the levels of CA125, ALDH1, YKL-4, PGF2α, IL-6, IL-18, TNF-α, E2, FSH, and LH in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.56%, respectively, and there were differences between two groups (P < 0.05). After treatment, CA125, ALDH1, YKL-4, and PGF2α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of E2, FSH, and LH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in
the control group, with significant difference between two groups (P< 0.05). After treatment, IL-6, IL-18, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Sanjie Zhentong Capsules combined with triptorelin has a significant clinical efficacy in treatment of endometriosis, can significantly improve the estrogen level, which has a certain clinical application value.
Pages: 1616-1620
Year: 2016 Issue: 10
Journal: World Phytomedicines
Keyword: Sanjie Zhentong Capsules; Triptorelin for injection; endometriosis; ALDH; YKL-4; FSH; LH;
Abstract: Objective To investigate the clinical efficacies of Sanjie Zhentong Capsules combined with triptorelin in treatment of endometriosis.Methods Children (90 cases) with endometriosis in Xi’an NO.4 Hospital from May 2012 to May 2015 were divided into control (45 cases) and treatment (45 cases) groups based on different treatment methods. Patients in the control group were im administered with Triptorelin for injection on the second day of the first menstruation after surgery, 3.75 mg/time, once every 4 weeks. Patients in the treatment group werepo administered with Sanjie Zhentong Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the levels of CA125, ALDH1, YKL-4, PGF2α, IL-6, IL-18, TNF-α, E2, FSH, and LH in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.56%, respectively, and there were differences between two groups (P < 0.05). After treatment, CA125, ALDH1, YKL-4, and PGF2α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of E2, FSH, and LH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in
the control group, with significant difference between two groups (P< 0.05). After treatment, IL-6, IL-18, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Sanjie Zhentong Capsules combined with triptorelin has a significant clinical efficacy in treatment of endometriosis, can significantly improve the estrogen level, which has a certain clinical application value.
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