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Correlation of microsatellite instability, vascular endothelial growth factor expression and pathological characteristics and prognosis in patients with colorectal cancer
Author(s): 
Pages: 615-618
Year: Issue:  4
Journal: Zhejiang Journal of Traumatic Surgery

Keyword:  微卫星不稳定血管内皮生长因子大肠癌病理特征预后;
Abstract: 目的 探讨分析微卫星不稳定(MSI)、血管内皮生长因子(VEGF)表达情况与大肠癌患者病理特征及预后相关性. 方法 回顾性分析本院107例行大肠癌根治术治疗的大肠癌患者临床病理资料,采用免疫组织化学方法检测107例患者手术标本肿瘤组织内MSI及VEGF表达情况,并比较MSI、VEGF表达与患者病理特征、预后相关性. 结果 MSI与患者淋巴结转移与浸润深度相关(P<0.05);VEGF表达与患者血行转移、淋巴结转移、TNM分期及浸润深度相关(P<0.05);高微卫星不稳定性(MSI-H)大肠癌VEGF的表达显著减少. 结论 MSI与大肠癌患者淋巴结转移与浸润深度相关,而VEGF表达与大肠癌患者血行转移、淋巴结转移、TNM分期与浸润深度相关,MSI-H患者其生存及预后情况显著优于MSS及MSI-L患者;VEGF阴性患者其生存情况显著优于VEGF阳性患者.MSI-H大肠癌与微卫星稳定性(MSS)大肠癌可能存在两种不同的新生血管形成的途径,MSI-H肿瘤较低的VEGF表达或许可解释为何MSI-H大肠癌有较低的侵袭性.
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