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gong jing huan xing dian qie shu he leng dao zhui qie shu zhi liao cin de dui bi yan jiu
Author(s): 
Pages: 629-631
Year: Issue:  4
Journal: Zhejiang Journal of Traumatic Surgery

Keyword:  宫颈环行电切术冷刀锥切术宫颈上皮内Ⅲ级瘤变;
Abstract: 目的 对比分析宫颈环行电切术(Loop electrosurgical excision procedure,LEEP)和冷刀锥切术(Cold knife conization,CKC)治疗宫颈上皮内Ⅲ级瘤变(Cervical intraepithelial neoplasia Ⅲ,CIN Ⅲ)的临床疗效和安全性. 方法 采用前瞻性研究方案,将63例CINⅢ随机分为两组,LEEP组32例,CKC31例,分别采用LEEP和CKC进行治疗.对比两组的临床手术情况、切缘阳性率、残留率、复发率、并发症发生率、生育保留率及妊娠结局. 结果 LEEP组手术时间短,术中出血量少,伤口愈合快,与CKC组相比,各项指标差异均有统计学意义(P<0.05).两组之间椎高和切缘阳性率差异无统计学意义(P>0.05),LEEP组残留率和复发率高于CKC组,并发症发生率低于CKC组,差异有统计学意义(P<0.05).LEEP妊娠率明显高于CKC组(P<0.05),但两组妊娠结局无统计学差异(P>0.05). 结论 LEEP术源性损伤小,利于保留患者生育功能,CKC根治率高,残留率和复发率低,可根据患者病情和需求灵活选择术式.
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