Effect of Mechanical Ventilation Combined with Pulmonary Surfactant in Neonates with Severe Pneumonia and Respiratory Failure
Author(s): Wu Jinglian, Juancheng County Hospital of Shandong Province
Pages: 18-21
Year: 2016 Issue: 10
Journal: Journal of Pediatric Pharmacy
Keyword: mechanical ventilation; pulmonary surfactant; neonates; severe pneumonia; respiratory failure;
Abstract: Objective: To evaluate the clinical efficacy of mechanical ventilation combined with pulmonary surfactant in neonates with severe pneumonia and respiratory failure. Methods: Seventy-six cases with severe pneumonia and respiratory failure treated in our hospital between January 2012 and December 2015 were analyzed retrospectively. Seventy six cases were given mechanical ventilation alone( control group,n = 31) or in combination with PS( observation group,n = 45). Therapeutic efficacy,blood gas parameters,lactate levels,oxygenation index,ventilator parameters,duration of mechanical ventilation,duration of oxygen inhalation,length of hospital stay,complications,and outcomes were observed in both groups. Results: The difference of oxygenation index of observation group( 284. 48 ± 48. 11) and control group( 237. 88 ± 49. 25) in the seventh day was statistically significant( P < 0. 05). Duration of mechanical ventilation,duration of oxygen inhalation,length of hospital stay in observation group were( 95. 46 ± 17. 41) h,( 96. 61 ±18. 09) h,( 21. 30 ± 4. 60) h,which were less than the control group of( 112. 58 ± 20. 21) h,( 116. 72 ± 28. 11) h,( 27. 12 ± 5. 14)h( P < 0. 05). Occurrence rates of ventilator-associated pneumonia,ventilator-associated lung injury in observation group( 8. 89%,2. 22%) were lower than the control group( 29. 03%,16. 13%,P < 0. 05). The differences of pneumothorax( 4. 44% vs 3. 22%),pulmonary hemorrhage( 2. 22% vs 6. 45%) had no statistical significance( P > 0. 05). The survival rate in observation group( 95. 55%) was higher than the control group( 80. 65%,P < 0. 05). Conclusion: Mechanical ventilation combined with pulmonary surfactant can effectively treat neonates with severe pneumonia and respiratory failure,which can effectively relieve symptoms,improve lung oxygenation,reduce complications and improve prognosis.
Pages: 18-21
Year: 2016 Issue: 10
Journal: Journal of Pediatric Pharmacy
Keyword: mechanical ventilation; pulmonary surfactant; neonates; severe pneumonia; respiratory failure;
Abstract: Objective: To evaluate the clinical efficacy of mechanical ventilation combined with pulmonary surfactant in neonates with severe pneumonia and respiratory failure. Methods: Seventy-six cases with severe pneumonia and respiratory failure treated in our hospital between January 2012 and December 2015 were analyzed retrospectively. Seventy six cases were given mechanical ventilation alone( control group,n = 31) or in combination with PS( observation group,n = 45). Therapeutic efficacy,blood gas parameters,lactate levels,oxygenation index,ventilator parameters,duration of mechanical ventilation,duration of oxygen inhalation,length of hospital stay,complications,and outcomes were observed in both groups. Results: The difference of oxygenation index of observation group( 284. 48 ± 48. 11) and control group( 237. 88 ± 49. 25) in the seventh day was statistically significant( P < 0. 05). Duration of mechanical ventilation,duration of oxygen inhalation,length of hospital stay in observation group were( 95. 46 ± 17. 41) h,( 96. 61 ±18. 09) h,( 21. 30 ± 4. 60) h,which were less than the control group of( 112. 58 ± 20. 21) h,( 116. 72 ± 28. 11) h,( 27. 12 ± 5. 14)h( P < 0. 05). Occurrence rates of ventilator-associated pneumonia,ventilator-associated lung injury in observation group( 8. 89%,2. 22%) were lower than the control group( 29. 03%,16. 13%,P < 0. 05). The differences of pneumothorax( 4. 44% vs 3. 22%),pulmonary hemorrhage( 2. 22% vs 6. 45%) had no statistical significance( P > 0. 05). The survival rate in observation group( 95. 55%) was higher than the control group( 80. 65%,P < 0. 05). Conclusion: Mechanical ventilation combined with pulmonary surfactant can effectively treat neonates with severe pneumonia and respiratory failure,which can effectively relieve symptoms,improve lung oxygenation,reduce complications and improve prognosis.
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